You'll need to verify their licensing model. Many companies are going to Office365, but buying the license that includes local Office applications vs. cloud only. As long as you have access to local Office applications, you have full access to Windchill Desktop Integration and Windchill. Once the content files are uploaded and stored in the Office365 (SharePoint) cloud, the only Windchill integration is a URL Link Document. Not sure why everyone thinks Office365 and SharePoint are different from traditional ECM or DM solutions; once you've vaulted your files in another system, that is the system of record.
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